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- 19 de junho de 2022
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After a penetrating lesion in the central nervous system, astrocytes enlarge, divide, and take part in creating an environment that adversely affects neuronal regeneration. We have lately proven that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals had been lesioned in the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at outlined stereotaxic positions. On one aspect, the lesions had been concomitantly infused with N-CAM or with one of the N-CAM-related molecules. As a control fre sex cams, a peptide of the same composition as the N-CAM decapeptide but of random sequence was infused on the contralateral facet of the brain. The inhibition was greatest in the cortical lesion sites (approximately 50%) and was less pronounced in the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical websites infused with N-CAM continued to exhibit a considerably smaller population of dividing astrocytes than the websites on the alternative side.
Del Rio JA, Soriano E. Immunocytochemical detection of 5′-bromodeoxyuridine incorporation in the central nervous system of the mouse. Giulian D, Chen J, Ingeman JE, George JK, Noponen M. The role of mononuclear phagocytes in wound healing after traumatic harm to adult mammalian brain. Smith GM, Rutishauser U, Silver J, Miller RH. Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth. Full textual content is on the market as a scanned copy of the unique print version. Get a printable copy of the entire article (1.6M), or click on on a web page image below to browse page by web page. Links to PubMed are also out there for Selected References. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice.
- Rudge JS, Silver J. Inhibition of neurite outgrowth on astroglial scars in vitro.
- A combined immunocytochemical and autoradiographic study.
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- On one facet, the lesions were concomitantly infused with N-CAM or with one of many N-CAM-related molecules.
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Alonso G, Privat A. Reactive astrocytes involved in the formation of lesional scars differ within the mediobasal hypothalamus and in other forebrain regions. Brodkey JA, Gates MA, Laywell ED, Steindler DA. The complex nature of interactive neuroregeneration-related molecules. Rudge JS, Silver J. Inhibition of neurite outgrowth on astroglial scars in vitro. Applications of Proteomics to Nerve Regeneration Research. Birding, and alternatives to help chook conservation. Get the newest information from us on the way to develop your small business – delivered straight to your inbox.
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